Zhu, “Anti-apoptotic effect of esculin on dopamine-induced cytotoxicity in the human neuroblastoma SH-SY5Y cell line,”, I. Lahmar, H. Belghith, F. Ben Abdallah, and K. Belghith, “Nutritional composition and phytochemical, antioxidative, and antifungal activities of Pergularia tomentosa L,”, A. Mohammadi, H. Nazari, S. Imani, and H. Amrollahi, “Antifungal activities and chemical composition of some medicinal plants,”, C. Y. Kwan, “Vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs,”, N. López-Carreras, S. Fernández-Vallinas, M. Miguel, and A. Aleixandre, “Long-term effect of an aqueous Fraxinus excelsior L. seed extract in spontaneously hypertensive rats,”, M. Eddouks, M. Maghrani, N.-A. leaves against CCl4 induced hepatic toxicity in rat,”, E. M. Ede, “Cellular oxidative stress and antioxidant enzymes,”, S. Chen, M. Ju, Y. Luo et al., “Hepatoprotective and antioxidant activities of the aqueous: extract from the rhizome of phragmites Australis,”, S. A. Ganie, T. A. Dar, B. Zargar et al., “Antioxidant and hepatoprotective effects of crataegus songarica methanol extract,”, A. Accumulated data by researchers commend that apoptosis induction in cancerous cells can result from various biological chemopreventive and chemotherapeutic agents [66–71]. Phytochemicals obtained from medicinal plants, herbs, seeds, and fruits such as phenolic compounds (terpenoids, flavonoids, and carotenoids) have shown promising effects in suppressing proliferation and thus are anticarcinogenic [62]. The concern of resistance provoked the need of effective and eco-friendly alternatives [83]. Fraxinus excelsior, commonly called European ash or common ash, is native to Europe and western Asia.It is a large, rounded, deciduous tree that grows to 70-80’ (less frequently to 140’) tall. Esculetin, esculin, fraxin, and fraxetin are some of the pharmacologically active components isolated from different species of Fraxinus plant (Figure 2). The bark and leaf are used to make medicine. 94 plant name records match your search criteria Fraxinus excelsior.The results are below. It is also used for gout, joint pain , … Goldenrod is used to reduce pain and swelling (inflammation), as a diuretic to increase urine flow, and to stop muscle spasms. Lipopolysaccharide (LPS) and interferon-gamma induced murine macrophage-like RAW 264.7 cells treatment by Fraxinus rhynchophylla extract showed an inhibition trend towards the amount of iNOS protein in dose-dependent manner suggesting its possible application as anti-inflammatory agent in autoimmune and chronic inflammatory diseases [74]. Príhoda, Antonín, Ladislav Urban & Vera Nicová: The following two tabs change content below. 2017, Article ID 4269868, 12 pages, 2017. https://doi.org/10.1155/2017/4269868, 1Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Punjab 38000, Pakistan, 2Department of Zoology, Faculty of Life Sciences, University of Sargodha, Punjab 40100, Pakistan. Cell signaling pathways are the main pillars behind cell communication as they are essential for the regulation of cell proliferation and survival. Photo Locations: Morton Arboretum - Lisle, IL, Strybing Arboretum - San Francisco, CA, Hoyt Arboretum - Portland, OR, Los Angeles County Arboretum - Arcadia, CA and Arnold Arboretum - Boston, MA. Treatment of streptozotocin- (STZ-) induced diabetic rats by Fraxinus angustifolia leaf extract (25 and 50 mg/kg) resulting in considerable hypoglycemic effects with significant reduction in malondialdehyde levels in short interval of time providing a way for the treatment of diabetes [106]. These cookies do not store any personal information. Fraxinus excelsior (European Ash) Fraxinus excelsior (European Ash) is a splendid, large, deciduous tree with a straight trunk and a dense, rounded crown. In vitro evaluations of antitoxoplasma activity of oleuropein and its metabolites isolated from Fraxinus rhynchophylla showed a good efficacy and higher selectivity as an anti-T. gondii compound. Aggregated data have revealed a variety of bioactive medicinal components from different species of Fraxinus plant that exhibit various biological activities (Table 1). Related Links. Various studies conducted by researchers have reported that natural products have anticancer [9, 10], antibacterial [11], antifungal [12], antiviral [13], antioxidant [14, 15], anthelmintic [16], and anti-inflammatory [17, 18] activities. Fraxinus plant derivative analogs along with pharmacodynamics and pharmacokinetics may also strengthen future advances. Xuan, “Water-soluble constituents of the root barks of Fraxinus rhynchophylla (Chinese drug Qinpi),”, J.-H. Jiang, C.-M. Jin, Y.-C. Kim, H.-S. Kim, W.-C. Park, and H. Park, “Anti-toxoplasmosis effects of oleuropein isolated from Fraxinus rhychophylla,”, M. H. Kim, J. Min, J. Y. Lee et al., “Oleuropein isolated from Fraxinus rhynchophylla inhibits glutamate-induced neuronal cell death by attenuating mitochondrial dysfunction,”, Y.-C. Tien, J.-C. Liao, C.-S. Chiu et al., “Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats,”, R. A. Macahig, L. Harinantenaina, K. Matsunami, H. Otsuka, Y. Takeda, and T. Shinzato, “Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii,”, S. Lin, M. T. Liu, S. J. Wang et al., “Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity,”, S. Lin, S. Wang, M. Liu et al., “Glycosides from the stem bark of Fraxinus sieboldiana,”, H. J. Kim, Y. G. Yu, H. Park, and Y. S. Lee, “HIV gp41 binding phenolic components from Fraxinus sieboldiana var. Regulatory circuits and molecular machineries that govern cellular function and fate are mainly disrupted by oncogenic mutations, conferring tumor cells towards various traits that assist their malignant behavior. Partner, Advertising & Commercial Relationships. Yang, S.-I. About 80% of the population globally depends upon the botanical drugs mainly from medicinal plants [8]. Latin name: Fraxinus excelsior Family: Oleaceae (Olive Family) Medicinal use of Ash: The leaves are astringent, cathartic, diaphoretic, mildly diuretic, laxative and purgative. Compounds isolated from various species of, Some of the biologically active compounds isolated from, A diagram representing the molecular targets and mechanism of action for, Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Punjab 38000, Pakistan, Department of Zoology, Faculty of Life Sciences, University of Sargodha, Punjab 40100, Pakistan, Evidence-Based Complementary and Alternative Medicine, Antioxidant, anti-inflammatory, wound healing potential, Nuzhenide, GI3, GI5, ligstroside, oleoside 11-methyl ester, 1′′′-O-beta-D-glucosylformoside, excelsides A, excelsides B, oleoside dimethyl ester, coumarins, Antihypertensive, antihypertriglyceridemia, adipocyte differentiation inhibitory activity, antidiabetic, antihyperglycaemic, anti-inflammatory, antirheumatic, Hydroxyframoside B 2′′-hydroxyoleuropein, oleuropein, ligstroside, syringin, esculin, fraxetin, fraxetin-8-O-[11′-methyl-oleosidyl-(7′→ 6′′)]-beta-D-glucopyranoside, esculetin, Pancreatic lipase inhibitory activity, inhibitor of adipocyte differentiation in 3T3-L1 cells, neuroprotective (protection against Abeta (25–35)-induced neuronal toxicity), antidyslipidemia, renoprotective, metal and free radical induced LDL oxidation inhibitor, antiatherosclerosis, antioxidant, PTP1B inhibitor, antitoxoplasmosis, glutamate-induced neuronal HT-22 cell death inhibition, hepatoprotective, 7-epi-7-O-(E)-caffeoylloganic acid, griffithosides C, Abietane, C20-norabietane, 6, 7-di-O-beta-D-glucopyranosylesculetin, aromatic glycosides, plantasioside, Calceolarioside B, Esculetin, Antioxidant against DPPH radicals, antiphotoaging, quinone reductase (QR) inducing activity, Immunosuppressant (inhibition of IL-2 and IgE production in mouse spleen cells and U266 cells), Antioxidant, antifungal (MIC = 1.8–3.8 mg/mL), Anti-inflammatory against zymosan- and carrageenan-induced paw oedema, Analgesic, anti-inflammatory (superoxide scavenging effects on the xanthine-xanthine oxidase-cytochrome c system), PKB phosphorylation⊥, Mcl-1↓, ERK-1/2⊥, Anti-inflammatory effect of oleuropein on LPS-induced BV-2 microglial cells, Protective effects of methanolic extract from, Modulation of cytokine expression by 5-methoxyl aesculetin (MOA) in LPS-stimulated RAW264.7 macrophages, Protective activities of methanolic extract of, T-cell activation⊥, arachidonic acid cascade⊥, Y. Luo, R. E. Cobb, and H. Zhao, “Recent advances in natural product discovery,”, A. Rasul, F. M. Millimouno, W. Ali Eltayb, M. Ali, J. Li, and X. Li, “Pinocembrin: a novel natural compound with versatile pharmacological and biological activities,”, A. L. Harvey, R. Edrada-Ebel, and R. J. Quinn, “The re-emergence of natural products for drug discovery in the genomics era,”, M. J. Balunas and A. D. Kinghorn, “Drug discovery from medicinal plants,”, A. G. Atanasov, B. Waltenberger, and E. M. Pferschy-Wenzig, “Discovery and resupply of pharmacologically active plant-derived natural products: a review,”, D. J. Newman and G. M. Cragg, “Natural products as sources of new drugs from 1981 to 2014,”, D. J. Newman, G. M. Cragg, and K. M. Snader, “Natural products as sources of new drugs over the period 1981–2002,”, T. Sen and S. K. Samanta, “Medicinal plants, human health and biodiversity: a broad review,”, N. Engel, A. Falodun, J. Kühn, U. Kragl, P. Langer, and B. Nebe, “Pro-apoptotic and anti-adhesive effects of four African plant extracts on the breast cancer cell line MCF-7,”, J. Paul, R. Gnanam, R. M. Jayadeepa, and L. Arul, “Anti cancer activity on graviola, an exciting medicinal plant extract vs various cancer cell lines and a detailed computational study on its potent anti-cancerous leads,”, V. Kuete, S. Alibert-Franco, K. O. Eyong et al., “Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype,”, A. Mollataghi, E. Coudiere, A. H. A. Hadi et al., “Anti-acetylcholinesterase, anti-, M. Son, M. Lee, G.-H. Toxoplasmosis, an intracellular parasitic protozoan infection caused by Toxoplasma gondii, is usually asymptomatic but has serious clinical manifestations in immunocompromised individuals [100]. In northern areas of Pakistan, root bark and leaves of Fraxinus plant have been traditionally used for the cure of malaria and pneumonia [27]. Most of the studies focus on few chemical constituents and data about the pharmacokinetics of the whole plant extract is limited. Esculetin (coumarin) isolated from Fraxinus rhynchophylla notably meliorated CCl4 induced hepatic toxicity by downregulating the aspartate aminotransferase and serum alanine aminotransferase and via upregulation of GSH-Px, SOD, and CAT and thus prevented the pathological condition associated with tissue injury [43]. Fraxinus excelsior, known as the ash, or European ash or common ash to distinguish it from other types of ash, is a flowering plant species in the olive family Oleaceae.It is native throughout mainland Europe east to the Caucasus and Alborz mountains, and the British Isles which determine its western boundary. Nyugat-palearktikus faj: az északi félteke mérsékelt övi erdeiben él. (EC50 = 139 mg/ml) [41]. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fraxetin (one of the main constituents of Fraxinus rhynchophylla) inhibitory effects against Staphylococcus aureus proliferation were investigated by treatment of bacterial cultures with fraxetin at a concentration of 0.05 mg/ml. Even though inflammatory response varies among different diseases, principally diseased condition is linked with the production of prostaglandins which are formed from arachidonate by the action of cyclooxygenase (COX) isoenzymes. Review articles are excluded from this waiver policy. Zhang, Y.-J. Get premium, high resolution news photos at Getty Images The have been used as a laxative, making a mild substitute for senna pods. Inflammation of the mouth and throat, when applied directly. A novel compound fraxetin isolated from Fraxinus rhynchophylla showed dual antioxidative functions against metal and free radicals induced low density lipoprotein (LDL) oxidation. Sung et al., “Bioactive activities of natural products against herpesvirus infection,”, M. Alaniia, K. Shalashvili, T. Sagareishvili, N. Kavtaradze, and M. Sutiashvili, “Study of antioxidant activity of phenolic compounds from some species of Georgian flora,”, U. R. Chatterjee, S. S. Bandyopadhyay, D. Ghosh, P. K. Ghosal, and B. Ray, “In vitro anti-oxidant activity, fluorescence quenching study and structural features of carbohydrate polymers from Phyllanthus emblica,”, P. M. Guarrera, “Traditional antihelmintic, antiparasitic and repellent uses of plants in Central Italy,”, A. Azab, A. Nassar, and A. N. Azab, “Anti-inflammatory activity of natural products,”, E. Fasano, S. Serini, N. Mondella et al., “Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines,”, M.-J. The details of all the compiled information concerning the effective inhibitory concentrations and molecular targets of bioactive components isolated from Fraxinus species are recorded in Table 2. Here, we have reviewed anticancer activities of Fraxinus plant with an intent to provide a clear image to researchers about this medically important plant. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Inhibition of dihydrofolate reductase by aqueous ethanolic extract of Fraxinus excelsior is one of the possible mechanisms behind its anti-inflammatory activity [75]. Esculetin has been extensively used in Chinese herbal medicine due to its vast pharmacological activities such as antioxidant, anticancer, antibacterial, and anti-inflammatory [30]. Fraxinus excelsior. The leaves of the fraxinus excelsior tree have a reportedly diuretic and purgative effect. He, G.-Y. This website uses cookies to improve your experience while you navigate through the website. You also have the option to opt-out of these cookies. This region has been shown to be an important reserve of bioactive medicinal plants in which phytotherapy knowledge has been and remains to be very developed (Eddouks et al., 2002). Fraxinus excelsior is a deciduous Tree growing to 30 m (98ft) by 20 m (65ft) at a fast rate. Fraxinus presents pharmacological effectiveness by targeting the novel targets in several pathological conditions, which provide a spacious therapeutic time window. Committee on Herbal Medicinal Products (HMPC) Assessment report on Fraxinus excelsior L. and Fraxinus angustifolia Vahl, folium . Pae, Y.-S. Ko et al., “In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla,”, E. Strehl, W. Schneider, and E. F. Elstner, “Inhibition of dihydrofolate reductase activity by alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea,”, T. Younis, M. R. Khan, and M. Sajid, “Protective effects of Fraxinus xanthoxyloides (Wall.) Much remains to be discovered about MOA as a propitious therapeutic agent for inflammatory diseases [59]. Identification and isolation of lead structures from hydroethanolic extract for novel antidiabetic drug development are commended [107]. In vitro assessment of hydroxyframoside B isolated from ethanolic extract of stem bark of Fraxinus rhynchophylla provided an approach to decrease obesity via downregulating the pancreatic lipase activity thus restricting the absorption of lipid by pancreas [36]. This category only includes cookies that ensures basic functionalities and security features of the website. angustata,”, B.-C. Lee, S. Y. Lee, H. J. Lee et al., “Anti-oxidative and photo-protective effects of coumarins isolated from, L. Wang, F. Sun, X. Zhang, Z. Ma, and L. Cheng, “A secoiridoid with quinone reductase inducing activity from Cortex fraxini,”, Y. Chen, G. Xue, F. Liu, and X. Gong, “Immunosuppressive effect of extracts from leaves of Fraxinus Mandshurica Rupr,”, S. M’sou, M. Alifriqui, and A. Romane, “Phytochemical study and biological effects of the essential oil of Fraxinus dimorpha Coss & Durieu,”, Z. Stefanova, H. Neychev, N. Ivanovska, and I. Kostova, “Effect of a total extract from Fraxinus ornus stem bark and esculin on zymosan- and carrageenan-induced paw oedema in mice,”, W. S. Chang, C. C. Lin, S. C. Chuang, and H. C. Chiang, “Superoxide anion scavenging effect of coumarins,”, S. Kumar and P. Kashyap, “Antiproliferative activity and nitric oxide production of a methanolic extract of, S. Sardari, M. A. Shokrgozar, and G. Ghavami, “Cheminformatics based selection and cytotoxic effects of herbal extracts,”, Y.-K. Park, Y. R. Do, and B.-C. Jang, “Apoptosis of K562 leukemia cells by Abnobaviscum F®, a European mistletoe extract,”, S. Lin, Y. Zhang, M. Liu et al., “Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities,”, J. Fraxinus excelsior é uma espécie de árvores da família das Oleaceae, conhecida pelo nome comum de freixo. Glycosides isolated from the ethanolic extract of the bark of Fraxinus sieboldiana resulted in induction of apoptosis via activation of pro-caspase-8 in colorectal cancer HCT-8 cells [46]. Among them, 49% of anticancer drugs belong to natural products [6, 7]. Fraxinus excelsior L. – European ash Subordinate Taxa. Fraxinus excelsior was traditionally given to individuals to help pass kidney stones. Most of the plants that have high percentage of polyphenolic compounds have been widely used in cosmetics for their antiaging properties [102].

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